The Precursor to Diabetes Almost No One Knows They Have

This article, from Reuters, talks about patients who learn of their status of pre-diabetes, also called Metabolic Syndrome X, who can alter their lifestyle and likely would be able to reverse their disease. It's really simple, but not easy to do as change is uncomfortable to humans, but eating low glycemic foods, ensuring you get the nutrients in the right doses/amounts, and live some type of physical lifestyle is the formula. There it is, simple, but not easy to do.


Only about one in eight people with so-called pre-diabetes, often a precursor to full-blown disease, know they have a problem, a U.S. study found. Lacking awareness, people with the elevated blood sugar levels were also less likely to make lifestyle changes such as getting more exercise or eating less sugary food that might prevent them from ultimately becoming diabetic.

“People with pre-diabetes who lose a modest amount of weight and increase their physical activity are less likely to develop diabetes,” lead study author Dr. Anjali Gopalan, a researcher at the Philadelphia VA Medical Center, said by email. “Our study importantly shows that individuals with pre-diabetes who were aware of this diagnosis were more likely to engage in some of these effective and recommended healthy lifestyle changes." Globally, about one in nine adults have diabetes, and the disease will be the seventh leading cause of death by 2030, according to the World Health Organization. Most of these people have Type 2, or adult-onset, diabetes, which happens when the body can’t properly use or make enough of the hormone insulin to convert blood sugar into energy.

Average blood sugar levels over the course of several months can be estimated by measuring changes to the hemoglobin molecule in red blood cells. The hemoglobin A1c test measures the percentage of hemoglobin - the protein in red blood cells that carries oxygen - that is coated with sugar, with readings of 6.5 percent or above signaling diabetes. But A1C levels between 5.7 percent and 6.4 percent are considered elevated, though not yet diabetic. More than one third of U.S. adults have such elevated blood sugar levels and each year about 11 percent of them progress to having full-blown diabetes, Gopalan and colleagues note in the American Journal of Preventive Medicine. To gauge awareness of this heightened diabetes risk among people with the condition, researchers weeded out people who said they already had the disease. Then, they reviewed A1c test results for the rest.

Out of 2,694 adults with test results showing elevated A1c, only 288 people were aware of their status. People who were aware of their condition were about 30 percent more likely to exercise and get at least 150 minutes of moderate activity each week. They were also about 80 percent more likely to attempt weight loss and to have shed at least 7 percent of their body weight in the past year.

In 2014, the U.S. Preventive Services Task Force, a government-backed independent panel that reviews medical evidence, said that screening for diabetes risk does help to identify people headed for full-blown disease and can help some of them to avert it with medication and lifestyle changes. It’s possible that some patients in the current study had been told about their status but didn’t recall or didn’t understand the specific way researchers asked about the condition, said Dr. Laura Rosella, a public health researcher at the University of Toronto.

"The health care provider has to tell the patient that they don’t meet the criteria fordiabetes but they aren’t quite out of the woods, which can be a challenging concept to get across,” Rosella, who wasn’t involved in the study, said by email. “This challenge could explain the low awareness." Some patients may also have been tested for diabetes using another measurement known as an oral glucose tolerance test, which can get different results than screening for A1c, said Dr. Robert Cohen, a diabetes specialist at the University of Cincinnati College of Medicine. "People can pass by one and miss by the other and it is confusion,” Cohen, who wasn’t involved in the study, said by email. “Many labeled as pre-diabetes by A1c would havediabetes if tested by the gold standard oral glucose tolerance test.”



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The Disease Many Americans Don't Know They Have

Written by Laura Tedesco and published on Yahoo! Health, this article exposes the diabetes epidemic not only gripping Americans but overwhelming our youth.

An alarming number of Americans are suffering from diabetes, a potentially deadly disease, without even knowing it.

Editor’s Note: The data in this study did not permit the researchers to separately analyze type 1 and type 2 diabetes, though 90 to 95 percent of cases are known to be type 2. Although type 1, or insulin-dependent diabetes, may be better diagnosed and more prevalent among young people, distinguishing the two diseases would not significantly alter the findings or recommendations, the researchers say.

You’d think a disease that can cause blindness, leads to amputations, and is the seventh leading cause of death in the United States would incite mass panic.

Yet Americans — and even some doctors — don’t take diabetes very seriously. (Did you even know it’s American Diabetes Month?) “Sometimes, people think ‘serious’ means things that kill you right away,” said Dr. Carlos del Rio, chair of the Emory University Department of Global Health. “But, the reality is, I would be more concerned about diabetes than Ebola.”

This lax attitude toward the disease may explain why nearly 30 percent of Americans who have diabetes don’t realize it, according to a new study in the Annals of Internal Medicine, conducted by del Rio and other Emory University scientists. They analyzed health data for 29,353 people from the National Health and Nutritional Examination Survey, identifying those with diabetes based on levels of fasting glucose and hemoglobin A1C (an indicator of blood-sugar control).

Overall, about 12 percent of all U.S. adults had diabetes, which translated to 28.4 million people in 2012. Among those, nearly 8 million hadn’t been diagnosed — a stat that’s made all the more alarming by the fact that most regularly went to the doctor: Two-thirds of undiagnosed diabetics had seen a health care provider at least twice in the past year, the study found.

Going undiagnosed — or even just delaying the process — is asking for internal trouble. The longer diabetes goes untreated, the worse the outcome tends to be. “Once the disease sets in, it’s really progressive,” study co-author Mohammed Ali, an assistant professor of global health at Emory University, told Yahoo Health. “It may be slow in some cases, but it leads to really disabling and often fatal complications.” Common but scary outcomes include vascular disease, kidney disease, or eye disease, which can lead to blindness.

On the flip side, if you catch and control diabetes early, “patients are very likely to do well, in terms of delaying the onset of all these horrendous complications, preserving their quality of life,” said Ali.

Unfortunately, the nature of the disease means that patients who should be undergoing blood tests often slip through the cracks: Diabetes is typically asymptomatic until people develop serious complications, so doctors don’t necessarily have clear cues to prompt them to suggest testing early on (although weight, family history, and lifestyle should be a consideration). “Diabetes is the silent killer,” said del Rio.

And because the U.S. is a nation of episodic care — that is, we seek medical attention for specific symptoms, rather than as a matter of routine — doctors aren’t necessarily thinking about performing preemptive blood tests on high-risk people. Instead, they’re usually focusing on, say, the patient’s back-pain problem, and not his or her overall care.

However, doctors are only one part of the equation: Patients may not be proactive about seeking care, Ali said, perhaps as a result of a low perceived risk of diabetes, poor insurance coverage, or even just time constraints. In the study, young people (ages 18 to 44) were especially likely to go undiagnosed, probably because they seek care only if they feel sick. “With diabetes, you don’t feel bad per se,” said Ali. “There’s a whole lot going on inside you, but you don’t feel it.”

Even after patients are diagnosed, they aren’t necessarily controlling their diabetes. “We may not link them to care properly or maintain them in care,” said del Rio. “It’s a whole ‘cascade of care’ issue.” In the study, only about 1 in 5 diagnosed diabetics refrained from smoking and had achieved the targets for hemoglobin A1C, blood pressure, and LDL “bad” cholesterol.

An estimated 75 percent of those with known diabetes also had high blood pressure. “It’s a double whammy,” del Rio said. “High blood pressure impacts your blood vessels, and diabetes impacts your blood vessels. And it’s blood vessel disease that leads to stroke and heart disease.” In fact, diabetics are 1.5 times more likely to be hospitalized for a stroke and about 1.7 times more likely to die of heart disease than people without the disease, according to the American Diabetes Association.

“Basically, the guidelines say, ‘Don’t just focus on sugar,’” said Ali. “Do the whole ABCD: the A1C is the sugar measurement that we use, B is blood pressure, C is cholesterol, and D is do not smoke.”

So how can our health care system ensure diabetes is caught, as well as treated? The first step: Increasing the emphasis on primary care, so patients regularly see doctors who monitor their weight, cholesterol, blood sugar, and vital signs, while also assessing their family history. “Chronic diseases are not controlled by episodic care,” said del Rio. “You need to have somebody that monitors you regularly.”

And patients who are diagnosed shouldn’t be shy about voicing their concerns about the prescribed treatments — for example, side effects of diabetes drugs or a lack of time to exercise. That way, doctors can help devise solutions that patients are more likely to comply with.

It’s not entirely up to the patient to halt diabetes in its tracks, though. “We need to start focusing on [figuring out] the interventions we need to do in order to improve outcomes,” del Rio said. “I envision doing more testing, and not only in the health care settings.” He sees workplaces, community centers, churches, and even local fairs as potential diabetes testing sites, and once people are flagged for the disease, he believes insurance companies should consider getting involved.

“We could work with insurance providers to ensure people are actually getting their medications and not falling out of care,” said del Rio. “Because, at the end of the day, if we don’t pay for care now, we’re going to pay for care later when they develop renal disease and other complications.”

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